Human CD133/PROM1 protein (Recombinant) (N-His) (STJP003273)

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STJP003273
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CD133/PROM1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PROM1
Gene ID: 8842
Uniprot ID: PROM1_HUMAN
Immunogen Region: Ala179-Tyr433
Immunogen: Homo sapiens (Human)
Post Translational Modifications Isoform 1 and isoform 2 are glycosylated. Acetylation at Lys-225, Lys-257 and Lys-264 by NAT8 and NAT8B may control PROM1 protein expression and its function in cell apoptosis.
Function May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner.
Protein Name Prominin-1
Antigen Ac133
Prominin-Like Protein 1
Cd Antigen Cd133
Cellular Localisation Apical Cell Membrane
Multi-Pass Membrane Protein
Cell Projection
Microvillus Membrane
Cilium
Photoreceptor Outer Segment
Endoplasmic Reticulum
Endoplasmic Reticulum-Golgi Intermediate Compartment
Found In Extracellular Membrane Particles In Various Body Fluids Such As Cerebrospinal Fluid
Saliva
Seminal Fluid And Urine
Alternative Protein Names Prominin-1 protein
Antigen Ac133 protein
Prominin-Like Protein 1 protein
Cd Antigen Cd133 protein
PROM1 protein
PROML1 protein
MSTP061 protein

Information sourced from Uniprot.org