| Post Translational Modifications | A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding). Rapidly phosphorylated on Tyr-496 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1. |
| Function | Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells. |
| Protein Name | Interleukin-1 Receptor Type 1Il-1r-1Il-1rt-1Il-1rt1Cd121 Antigen-Like Family Member AInterleukin-1 Receptor AlphaIl-1r-AlphaInterleukin-1 Receptor Type IP80Cd Antigen Cd121a Cleaved Into - Interleukin-1 Receptor Type 1 - Membrane FormMil-1r1Mil-1ri - Interleukin-1 Receptor Type 1 - Soluble FormSil-1r1Sil-1ri |
| Database Links | Reactome: R-HSA-6783783Reactome: R-HSA-9020702Reactome: R-HSA-9679191 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinCell MembraneSecreted |
| Alternative Protein Names | Interleukin-1 Receptor Type 1 proteinIl-1r-1 proteinIl-1rt-1 proteinIl-1rt1 proteinCd121 Antigen-Like Family Member A proteinInterleukin-1 Receptor Alpha proteinIl-1r-Alpha proteinInterleukin-1 Receptor Type I proteinP80 proteinCd Antigen Cd121a Cleaved Into - Interleukin-1 Receptor Type 1 - Membrane Form proteinMil-1r1 proteinMil-1ri - Interleukin-1 Receptor Type 1 - Soluble Form proteinSil-1r1 proteinSil-1ri proteinIL1R1 proteinIL1R proteinIL1RA proteinIL1RT1 protein |
Information sourced from Uniprot.org
