Human CD120b/TNFRSF1B/TNFR2 protein (Recombinant-Active) (C-Fc) (STJP012515)

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STJP012515-100
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Host: Mammalian Cells
Applications: ELISA/WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Active-Human CD120b/TNFRSF1B/TNFR2-C-Fc protein was developed from mammalian cells and has a target region of C-Fc. For use in research applications.
Conjugation: Unconjugated
Formulation: Lyophilized from a 0.22 Mu m filtered solution in PBS, pH 7.4.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: < 1 EU/µg as determined by LAL test.
Gene Symbol: TNFRSF1B
Gene ID: 7133
Uniprot ID: TNR1B_HUMAN
Immunogen Region: Leu23-Asp257
Immunogen: Homo sapiens (Human)
Function Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
Protein Name Tumor Necrosis Factor Receptor Superfamily Member 1b
Tumor Necrosis Factor Receptor 2
Tnf-R2
Tumor Necrosis Factor Receptor Type Ii
Tnf-Rii
Tnfr-Ii
P75
P80 Tnf-Alpha Receptor
Cd Antigen Cd120b
Etanercept Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1b - Membrane Form - Tumor Necrosis Factor-Binding Protein 2
Tbp-2
Tbpii
Database Links Reactome: R-HSA-5668541
Reactome: R-HSA-5669034
Reactome: R-HSA-6783783
Reactome: R-HSA-6785807
Reactome: R-HSA-6798695
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Secreted
Tumor Necrosis Factor-Binding Protein 2: Secreted
Alternative Protein Names Tumor Necrosis Factor Receptor Superfamily Member 1b protein
Tumor Necrosis Factor Receptor 2 protein
Tnf-R2 protein
Tumor Necrosis Factor Receptor Type Ii protein
Tnf-Rii protein
Tnfr-Ii protein
P75 protein
P80 Tnf-Alpha Receptor protein
Cd Antigen Cd120b protein
Etanercept Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1b - Membrane Form - Tumor Necrosis Factor-Binding Protein 2 protein
Tbp-2 protein
Tbpii protein
TNFRSF1B protein
TNFBR protein
TNFR2 protein

Information sourced from Uniprot.org

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