Human CD112/Nectin-2/PVRL2 protein (Recombinant-Active) (C-hFc-His) (STJP012217)

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STJP012217-100
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Active-Human CD112/Nectin-2/PVRL2-C-hFc-His protein was developed from mammalian cells and has a target region of C-hFc-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: <0.1 EU/Mu g of the protein by the LAL method.
Gene Symbol: NECTIN2
Gene ID: 5819
Uniprot ID: NECT2_HUMAN
Immunogen Region: Gln32-Gly360
Immunogen: Homo sapiens (Human)
Function Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein. (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).
Protein Name Nectin-2
Herpes Virus Entry Mediator B
Herpesvirus Entry Mediator B
Hveb
Nectin Cell Adhesion Molecule 2
Poliovirus Receptor-Related Protein 2
Cd Antigen Cd112
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-418990
Reactome: R-HSA-420597
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Nectin-2 protein
Herpes Virus Entry Mediator B protein
Herpesvirus Entry Mediator B protein
Hveb protein
Nectin Cell Adhesion Molecule 2 protein
Poliovirus Receptor-Related Protein 2 protein
Cd Antigen Cd112 protein
NECTIN2 protein
HVEB protein
PRR2 protein
PVRL2 protein

Information sourced from Uniprot.org

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