Human CD107a/LAMP1 protein (Recombinant) (C-His) (STJP007028)

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STJP007028
£469.50 - £2,492.50
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CD107a/LAMP1-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: LAMP1
Gene ID: 3916
Uniprot ID: LAMP1_HUMAN
Immunogen Region: Met1-Met382
Immunogen: Homo sapiens (Human)
Function Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis. Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity. Also plays an important role in NK-cells cytotoxicity. Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule. In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content. Presents carbohydrate ligands to selectins. (Microbial infection) Acts as a receptor for Lassa virus glycoprotein. Promotes also fusion of the virus with host membrane in less acidic endosomes. (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F.
Protein Name Lysosome-Associated Membrane Glycoprotein 1
Lamp-1
Lysosome-Associated Membrane Protein 1
Cd107 Antigen-Like Family Member A
Cd Antigen Cd107a
Database Links Reactome: R-HSA-6798695
Cellular Localisation Lysosome Membrane
Single-Pass Type I Membrane Protein
Endosome Membrane
Late Endosome Membrane
Cell Membrane
Cytolytic Granule Membrane
This Protein Shuttles Between Lysosomes
Endosomes
And The Plasma Membrane
Colocalizes With Osbpl1a At The Late Endosome
Alternative Protein Names Lysosome-Associated Membrane Glycoprotein 1 protein
Lamp-1 protein
Lysosome-Associated Membrane Protein 1 protein
Cd107 Antigen-Like Family Member A protein
Cd Antigen Cd107a protein
LAMP1 protein

Information sourced from Uniprot.org