Human CD101 protein (Recombinant) (N-His) (STJP005813)

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STJP005813
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CD101-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CD101
Gene ID: 9398
Uniprot ID: IGSF2_HUMAN
Immunogen Region: Ala566-Leu784
Immunogen: Homo sapiens (Human)
Post Translational Modifications N-glycosylated.
Function Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells.
Protein Name Immunoglobulin Superfamily Member 2
Igsf2
Cell Surface Glycoprotein V7
Glu-Trp-Ile Ewi Motif-Containing Protein 101
Ewi-101
Cd Antigen Cd101
Database Links Reactome: R-HSA-202433
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Immunoglobulin Superfamily Member 2 protein
Igsf2 protein
Cell Surface Glycoprotein V7 protein
Glu-Trp-Ile Ewi Motif-Containing Protein 101 protein
Ewi-101 protein
Cd Antigen Cd101 protein
CD101 protein
EWI101 protein
IGSF2 protein
V7 protein

Information sourced from Uniprot.org

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