Host: |
E. coli |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : |
Recombinant-Human CCND3-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
Formulation: |
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
Storage Instruction: |
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Gene Symbol: |
CCND3 |
Gene ID: |
896 |
Uniprot ID: |
CCND3_HUMAN |
Immunogen Region: |
Met1-Leu292 |
Immunogen: |
Homo sapiens (Human) |
Function | Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Shows transcriptional coactivator activity with ATF5 independently of CDK4. |
Protein Name | G1/S-Specific Cyclin-D3 |
Database Links | Reactome: R-HSA-381340Reactome: R-HSA-5687128Reactome: R-HSA-69231Reactome: R-HSA-8934593Reactome: R-HSA-9661069Reactome: R-HSA-9754119 |
Cellular Localisation | NucleusCytoplasm |
Alternative Protein Names | G1/S-Specific Cyclin-D3 proteinCCND3 protein |
Information sourced from Uniprot.org