Human CCND3 protein (Recombinant) (N-His) (STJP004523)

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STJP004523
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CCND3-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CCND3
Gene ID: 896
Uniprot ID: CCND3_HUMAN
Immunogen Region: Met1-Leu292
Immunogen: Homo sapiens (Human)
Function Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Shows transcriptional coactivator activity with ATF5 independently of CDK4.
Protein Name G1/S-Specific Cyclin-D3
Database Links Reactome: R-HSA-381340
Reactome: R-HSA-5687128
Reactome: R-HSA-69231
Reactome: R-HSA-8934593
Reactome: R-HSA-9661069
Reactome: R-HSA-9754119
Cellular Localisation Nucleus
Cytoplasm
Alternative Protein Names G1/S-Specific Cyclin-D3 protein
CCND3 protein

Information sourced from Uniprot.org