| Short Description : | Recombinant-Human CCN4-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications: | ELISA/Immunogen/SDS-PAGE/WB |
| Host: | E.coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Dilution Range: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | CCN4 |
| Gene ID: | 8840 |
| Uniprot ID: | CCN4_HUMAN |
| Immunogen: | Homo sapiens (Human) |
| Immunogen Region: | Cys216-Arg347 |
| Function | Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan. |
| Protein Name | Ccn Family Member 4Wnt1-Inducible-Signaling Pathway Protein 1Wisp-1Wnt-1-Induced Secreted Protein |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Ccn Family Member 4 proteinWnt1-Inducible-Signaling Pathway Protein 1 proteinWisp-1 proteinWnt-1-Induced Secreted Protein proteinCCN4 proteinWISP1 protein |
Information sourced from Uniprot.org