| Function | Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan. |
| Protein Name | Ccn Family Member 4Wnt1-Inducible-Signaling Pathway Protein 1Wisp-1Wnt-1-Induced Secreted Protein |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Ccn Family Member 4 proteinWnt1-Inducible-Signaling Pathway Protein 1 proteinWisp-1 proteinWnt-1-Induced Secreted Protein proteinCCN4 proteinWISP1 protein |
Information sourced from Uniprot.org