Human CCL3/MIP-1 alpha protein (Recombinant) (N-hFc) (STJP003010)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human CCL3/MIP-1 alpha Protein is produced by E. coli expression system. The target protein is expressed with sequence (Ala23-Ala92 ) of Human CCL3/MIP-1 alpha (Accession #NP_002974.1) fused with no tag.
General Information
| Short Description | Recombinant-Human CCL3/MIP-1 alpha-N-hFc protein was developed in hek293 cells using the region Ala23-Ala92 . For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | CCL3 |
| Gene ID | 6348 |
| Uniprot ID | CCL3_HUMAN |
| Immunogen | Recombinant Human CCL3/MIP-1 alpha Protein is produced by E. coli expression system. The target protein is expressed with sequence (Ala23-Ala92 ) of Human CCL3/MIP-1 alpha (Accession #NP_002974.1) fused with no tag. |
| Immunogen Region | Ala23-Ala92 |
| Immunogen Sequence | GPETLCGAELVDALQFVCGP RGFYFNKPTGYGSSIRRAPQ TGIVDECCFRSCDLRRLEMY CAPLKPTKAA |
Additional Info
| Post Translational Modifications | N-terminal processed form LD78-alpha(4-69) is produced by proteolytic cleavage after secretion from HTLV1-transformed T-cells. |
| Function | Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). |
| Protein Name | C-C Motif Chemokine 3G0/G1 Switch Regulatory Protein 19-1Macrophage Inflammatory Protein 1-AlphaMip-1-AlphaPat 464.1Sis-BetaSmall-Inducible Cytokine A3Tonsillar Lymphocyte Ld78 Alpha Protein Cleaved Into - Mip-1-Alpha(4-69Ld78-Alpha(4-69 |
| Database Links | Reactome: R-HSA-380108Reactome: R-HSA-6783783 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | C-C Motif Chemokine 3 proteinG0/G1 Switch Regulatory Protein 19-1 proteinMacrophage Inflammatory Protein 1-Alpha proteinMip-1-Alpha proteinPat 464.1 proteinSis-Beta proteinSmall-Inducible Cytokine A3 proteinTonsillar Lymphocyte Ld78 Alpha Protein Cleaved Into - Mip-1-Alpha(4-69 proteinLd78-Alpha(4-69 proteinCCL3 proteinG0S19-1 proteinMIP1A proteinSCYA3 protein |
Information sourced from Uniprot.org