Human CBX6 protein (Recombinant) (N-Strep) (STJP010084)

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STJP010084
£328.50 - £1,437.50
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CBX6-N-Strep protein was developed from e. coli and has a target region of N-Strep. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CBX6
Gene ID: 23466
Uniprot ID: CBX6_HUMAN
Immunogen Region: Met1-Lys412
Immunogen: Homo sapiens (Human)
Function Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones.it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin. Recruitment to chromatin might occur in an H3K27me3-independent fashion. May have a PRC1-independent function in embryonic stem cells.
Protein Name Chromobox Protein Homolog 6
Database Links Reactome: R-HSA-2559580
Reactome: R-HSA-8939243
Reactome: R-HSA-8943724
Cellular Localisation Nucleus
Chromosome
Uniformely Distributed In The Nucleoplasm
Localizes To The Inactivated X Chromosome In Females
Alternative Protein Names Chromobox Protein Homolog 6 protein
CBX6 protein

Information sourced from Uniprot.org

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