Human CBR4 protein (Recombinant) (His-Tag) (STJP016921)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human CBR4-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 5mM DTT, 200mM NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CBR4 |
| Gene ID | 84869 |
| Uniprot ID | CBR4_HUMAN |
| Accession Number | AAH21973.1 |
| Immunogen | Human |
| Immunogen Region | 1-237aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Detected in liver and kidney (at protein level). Displays the highest expression in neuronal and muscle tissues. |
| Function | Component of the heterotetramer complex KAR (3-ketoacyl-acyl carrier protein reductase or 3-ketoacyl-ACP reductase) that forms part of the mitochondrial fatty acid synthase (mtFAS). Beta-subunit of the KAR heterotetramer complex, responsible for the 3-ketoacyl-ACP reductase activity of the mtFAS, reduces 3-oxoacyl-ACP to (3R)-hydroxyacyl-ACP in a NADPH-dependent manner with no chain length preference, thereby participating in mitochondrial fatty acid biosynthesis. The homotetramer has NADPH-dependent quinone reductase activity (in vitro), hence could play a role in protection against cytotoxicity of exogenous quinones. As a heterotetramer, it can also reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro). |
| Protein Name | 3-Oxoacyl-Acyl-Carrier-Protein Reductase3-Ketoacyl-Acyl-Carrier-Protein Reductase Beta SubunitKar Beta SubunitCarbonyl Reductase Family Member 4Cbr4Quinone Reductase Cbr4Short Chain Dehydrogenase/Reductase Family 45c Member 1 |
| Database Links | Reactome: R-HSA-75105 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Protein Names | 3-Oxoacyl-Acyl-Carrier-Protein Reductase protein3-Ketoacyl-Acyl-Carrier-Protein Reductase Beta Subunit proteinKar Beta Subunit proteinCarbonyl Reductase Family Member 4 proteinCbr4 proteinQuinone Reductase Cbr4 proteinShort Chain Dehydrogenase/Reductase Family 45c Member 1 proteinCBR4 proteinSDR45C1 protein |
Information sourced from Uniprot.org