Human CASR protein (Recombinant) (N-His) (STJP007584)

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STJP007584
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CASR-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CASR
Gene ID: 846
Uniprot ID: CASR_HUMAN
Immunogen Region: Tyr63-Ser531
Immunogen: Homo sapiens (Human)
Post Translational Modifications N-glycosylated. Ubiquitinated by RNF19A.which induces proteasomal degradation.
Function G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis. Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation.
Protein Name Extracellular Calcium-Sensing Receptor
Car
Casr
Hcasr
Parathyroid Cell Calcium-Sensing Receptor 1
Pcar1
Database Links Reactome: R-HSA-416476
Reactome: R-HSA-418594
Reactome: R-HSA-420499
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Protein Names Extracellular Calcium-Sensing Receptor protein
Car protein
Casr protein
Hcasr protein
Parathyroid Cell Calcium-Sensing Receptor 1 protein
Pcar1 protein
CASR protein
GPRC2A protein
PCAR1 protein

Information sourced from Uniprot.org

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