| Host: |
E. coli |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
< 0.1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: |
GOT1 |
| Gene ID: |
2805 |
| Uniprot ID: |
AATC_HUMAN |
| Immunogen: |
Recombinant Human cAspAT/AATC/GOT1 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Ala2-Gln413) of human cAspAT (Accession #NP_002070.1). |
| Immunogen Sequence: |
APPSVFAEVPQAQPVLVFKL TADFREDPDPRKVNLGVGAY RTDDCHPWVLPVVKKVEQKI ANDNSLNHEYLPILGLAEFR SCASRLALGDDSPALKEKRV GGVQSLGGTGALRIGADFLA RWYNGTNNKNTPVYVSSPTW ENHNAVFSAAGFKDIRSYRY WDAEKRGLDLQGFLNDLENA PEFSIVVLHACAHNPTGIDP TPEQWKQIASVMKHRFLFPF FDSAYQGFASGNLERDAWA |
| Function | Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. In addition, catalyzes (2S)-2-aminobutanoate, a by-product in the cysteine biosynthesis pathway. |
| Protein Name | Aspartate Aminotransferase - CytoplasmicCaspatCysteine Aminotransferase - CytoplasmicCysteine Transaminase - CytoplasmicCcatGlutamate Oxaloacetate Transaminase 1Transaminase A |
| Database Links | Reactome: R-HSA-1237112Reactome: R-HSA-8963693Reactome: R-HSA-9856872 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Aspartate Aminotransferase - Cytoplasmic proteinCaspat proteinCysteine Aminotransferase - Cytoplasmic proteinCysteine Transaminase - Cytoplasmic proteinCcat proteinGlutamate Oxaloacetate Transaminase 1 proteinTransaminase A proteinGOT1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
