| Post Translational Modifications | Cleavages at Asp-315 by granzyme B and at Asp-330 by caspase-3 generate the two active subunits. Caspase-8 and -10 can also be involved in these processing events. Phosphorylated at Thr-125 by MAPK1/ERK2. Phosphorylation at Thr-125 is sufficient to block caspase-9 processing and subsequent caspase-3 activation. Phosphorylation on Tyr-153 by ABL1/c-Abl.occurs in the response of cells to DNA damage. (Microbial infection) ADP-riboxanation by C.violaceum CopC blocks CASP9 processing, preventing CASP9 activation and ability to mediate intrinsic apoptosis. Ubiquitinated by BIRC6.this activity is inhibited by DIABLO/SMAC. |
| Function | Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates effector caspases caspase-3 (CASP3) or caspase-7 (CASP7). Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC. Isoform 2: Lacks activity is an dominant-negative inhibitor of caspase-9. |
| Protein Name | Caspase-9Casp-9Apoptotic Protease Mch-6Apoptotic Protease-Activating Factor 3Apaf-3Ice-Like Apoptotic Protease 6Ice-Lap6 Cleaved Into - Caspase-9 Subunit P35 - Caspase-9 Subunit P10 |
| Database Links | Reactome: R-HSA-111458Reactome: R-HSA-111459Reactome: R-HSA-111463Reactome: R-HSA-111464Reactome: R-HSA-168638Reactome: R-HSA-198323Reactome: R-HSA-418889Reactome: R-HSA-5674400Reactome: R-HSA-9627069 |
| Alternative Protein Names | Caspase-9 proteinCasp-9 proteinApoptotic Protease Mch-6 proteinApoptotic Protease-Activating Factor 3 proteinApaf-3 proteinIce-Like Apoptotic Protease 6 proteinIce-Lap6 Cleaved Into - Caspase-9 Subunit P35 - Caspase-9 Subunit P10 proteinCASP9 proteinMCH6 protein |
Information sourced from Uniprot.org
