Human CASP5 protein (Recombinant) (N-His) (STJP004889)

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STJP004889
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CASP5-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CASP5
Gene ID: 838
Uniprot ID: CASP5_HUMAN
Immunogen Region: Ile182-Asp327
Immunogen: Homo sapiens (Human)
Post Translational Modifications The two subunits are derived from the precursor sequence by an autocatalytic mechanism.
Function Thiol protease that acts as a mediator of programmed cell death. Initiates pyroptosis, a programmed lytic cell death pathway through cleavage of Gasdermin-D (GSDMD): cleavage releases the N-terminal gasdermin moiety (Gasdermin-D, N-terminal) that binds to membranes and forms pores, triggering pyroptosis. Also mediates cleavage and maturation of IL18. Cleavage of GSDMD and IL18 is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP4. During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation.
Protein Name Caspase-5
Casp-5
Ice(Rel-Iii
Protease Ich-3
Protease Ty Cleaved Into - Caspase-5 Subunit P20 - Caspase-5 Subunit P10
Database Links Reactome: R-HSA-5620971
Alternative Protein Names Caspase-5 protein
Casp-5 protein
Ice(Rel-Iii protein
Protease Ich-3 protein
Protease Ty Cleaved Into - Caspase-5 Subunit P20 - Caspase-5 Subunit P10 protein
CASP5 protein
ICH3 protein

Information sourced from Uniprot.org

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