| Post Translational Modifications | ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination. Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation. |
| Function | Required for pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homomer. |
| Protein Name | Protein Casc3Cancer Susceptibility Candidate Gene 3 ProteinMetastatic Lymph Node Gene 51 ProteinMln 51Protein BarentszBtz |
| Database Links | Reactome: R-HSA-159236Reactome: R-HSA-72163Reactome: R-HSA-72187Reactome: R-HSA-73856Reactome: R-HSA-9010553Reactome: R-HSA-975957 |
| Cellular Localisation | CytoplasmPerinuclear RegionNucleusNucleus SpeckleStress GranuleCytoplasmic Ribonucleoprotein GranuleCell ProjectionDendriteShuttles Between The Nucleus And The Cytoplasm In A Xpo1/Crm1-Dependent MannerTransported To The Cytoplasm As Part Of The Exon Junction Complex (Ejc) Bound To MrnaIn Nuclear SpecklesColocalizes With MagohUnder Stress ConditionsColocalizes With Fmr1 And Tia1But Not Magoh And Rbm8a Ejc Core FactorsIn Cytoplasmic Stress GranulesIn The Dendrites Of Hippocampal NeuronsLocalizes To Dendritic Ribonucleoprotein Granules |
| Alternative Protein Names | Protein Casc3 proteinCancer Susceptibility Candidate Gene 3 Protein proteinMetastatic Lymph Node Gene 51 Protein proteinMln 51 proteinProtein Barentsz proteinBtz proteinCASC3 proteinMLN51 protein |
Information sourced from Uniprot.org
