Human CAPN2 protein (Recombinant) (N-His) (STJP004198)

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STJP004198
€410.63 - €1,796.88
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CAPN2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CAPN2
Gene ID: 824
Uniprot ID: CAN2_HUMAN
Immunogen Region: Leu45-Asp514
Immunogen: Homo sapiens (Human)
Function Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs.
Protein Name Calpain-2 Catalytic Subunit
Calcium-Activated Neutral Proteinase 2
Canp 2
Calpain M-Type
Calpain Large Polypeptide L2
Calpain-2 Large Subunit
Millimolar-Calpain
M-Calpain
Database Links Reactome: R-HSA-1474228
Reactome: R-HSA-8862803
Cellular Localisation Cytoplasm
Cell Membrane
Translocates To The Plasma Membrane Upon Ca(2+) Binding
Alternative Protein Names Calpain-2 Catalytic Subunit protein
Calcium-Activated Neutral Proteinase 2 protein
Canp 2 protein
Calpain M-Type protein
Calpain Large Polypeptide L2 protein
Calpain-2 Large Subunit protein
Millimolar-Calpain protein
M-Calpain protein
CAPN2 protein
CANPL2 protein

Information sourced from Uniprot.org

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