Human CAMKK2 (Calcium/Calmodulin Dependent Protein Kinase Kinase 2) Sandwich ELISA Kit Ready-To-Use Kit (STJE0014035)

Human CAMKK2 (Calcium/Calmodulin Dependent Protein Kinase Kinase 2) Sandwich ELISA Kit Ready-To-Use Kit (STJE0014035)

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STJE0014035
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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.114ng/mL
Detection Limit: 0.312-20ng/mL
Short Description : This CAMKK2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates or other biological fluids..
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: CAMKK2
Gene ID: 10645
Uniprot ID: KKCC2_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in spleen, prostate, thyroid and leukocytes. The lowest level is in lung.
Post Translational Modifications Autophosphorylated and phosphorylated by PKA. Each isoform may show a different pattern of phosphorylation.
Function Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals. Seems to be involved in hippocampal activation of CREB1. May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.
Protein Name Calcium/Calmodulin-Dependent Protein Kinase Kinase 2
Cam-Kk 2
Cam-Kinase Kinase 2
Camkk 2
Calcium/Calmodulin-Dependent Protein Kinase Kinase Beta
Cam-Kk Beta
Cam-Kinase Kinase Beta
Camkk Beta
Database Links Reactome: R-HSA-111932
Reactome: R-HSA-442729
Reactome: R-HSA-9619229
Reactome: R-HSA-9619483
Cellular Localisation Nucleus
Cytoplasm
Cell Projection
Neuron Projection
Predominantly Nuclear In Unstimulated Cells
Relocalizes Into Cytoplasm And Neurites After Forskolin Induction
Alternative ELISA Names Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 ELISA kit
Cam-Kk 2 ELISA kit
Cam-Kinase Kinase 2 ELISA kit
Camkk 2 ELISA kit
Calcium/Calmodulin-Dependent Protein Kinase Kinase Beta ELISA kit
Cam-Kk Beta ELISA kit
Cam-Kinase Kinase Beta ELISA kit
Camkk Beta ELISA kit
CAMKK2 ELISA kit
CAMKKB ELISA kit
KIAA0787 ELISA kit
output

Information sourced from Uniprot.org

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