| Host: | E.coli |
| Applications: | ELISA/Immunogen/SDS-PAGE/WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human CAMK2B-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Dilution Range: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | CAMK2B |
| Gene ID: | 816 |
| Uniprot ID: | KCC2B_HUMAN |
| Immunogen Region: | Met1-Lys301 |
| Immunogen: | Homo sapiens (Human) |
| Post Translational Modifications | Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state. |
| Function | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway. Phosphorylates reticulophagy regulator RETREG1 at 'Ser-151' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity. |
| Protein Name | Calcium/Calmodulin-Dependent Protein Kinase Type Ii Subunit BetaCam Kinase Ii Subunit BetaCamk-Ii Subunit Beta |
| Database Links | Reactome: R-HSA-111932Reactome: R-HSA-3371571Reactome: R-HSA-399719Reactome: R-HSA-438066Reactome: R-HSA-442729Reactome: R-HSA-442982Reactome: R-HSA-5576892Reactome: R-HSA-5578775Reactome: R-HSA-5673000Reactome: R-HSA-5673001Reactome: R-HSA-6802946Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-877300Reactome: R-HSA-9022692Reactome: R-HSA-936837Reactome: R-HSA-9609736Reactome: R-HSA-9617324Reactome: R-HSA-9620244Reactome: R-HSA-9649948Reactome: R-HSA-9656223 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSarcoplasmic Reticulum MembranePeripheral Membrane ProteinCytoplasmic SideSynapseIn Slow-Twitch MuscleEvenly Distributed Between Longitudinal Sr And Junctional Sr |
| Alternative Protein Names | Calcium/Calmodulin-Dependent Protein Kinase Type Ii Subunit Beta proteinCam Kinase Ii Subunit Beta proteinCamk-Ii Subunit Beta proteinCAMK2B proteinCAM2 proteinCAMK2 proteinCAMKB protein |
Information sourced from Uniprot.org