| Function | Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy. |
| Protein Name | CalreticulinCrp55CalregulinEndoplasmic Reticulum Resident Protein 60Erp60HacbpGrp60 |
| Database Links | Reactome: R-HSA-1236974Reactome: R-HSA-168316Reactome: R-HSA-3000480Reactome: R-HSA-3000484Reactome: R-HSA-381183Reactome: R-HSA-901042Reactome: R-HSA-983170 |
| Cellular Localisation | Endoplasmic Reticulum LumenCytoplasmCytosolSecretedExtracellular SpaceExtracellular MatrixCell SurfaceSarcoplasmic Reticulum LumenCytoplasmic VesicleSecretory VesicleCortical GranuleCytolytic GranuleAlso Found In Cell Surface (T Cells)Cytosol And Extracellular MatrixDuring Oocyte Maturation And After Parthenogenetic Activation Accumulates In Cortical GranulesIn Pronuclear And Early Cleaved Embryos Localizes Weakly To Cytoplasm Around Nucleus And More Strongly In The Region Near The CortexIn Cortical Granules Of Non-Activated OocytesIs Exocytosed During The Cortical Reaction In Response To Oocyte Activation |
| Alternative Protein Names | Calreticulin proteinCrp55 proteinCalregulin proteinEndoplasmic Reticulum Resident Protein 60 proteinErp60 proteinHacbp proteinGrp60 proteinCALR proteinCRTC protein |
Information sourced from Uniprot.org
