Human CADM1 protein (Recombinant-Active) (C-His) (STJP012246)

SKU:
STJP012246-100
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Active-Human CADM1-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: <0.1 EU/Mu g of the protein by the LAL method.
Gene Symbol: CADM1
Gene ID: 23705
Uniprot ID: CADM1_HUMAN
Immunogen Region: Ile39-Ala375
Immunogen: Homo sapiens (Human)
Function Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. By interacting with CRTAM and thus promoting the adhesion between CD8+ T-cells and CD8+ dendritic cells, regulates the retention of activated CD8+ T-cell within the draining lymph node. Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells. Interaction with CRTAM promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. May contribute to the less invasive phenotypes of lepidic growth tumor cells. Isoform 5: (Microbial infection) Induces cell fusion in neuron infected by a neuropathogenic strain of measles.Interacts with measles hemagglutinin to trigger hyperfusogenic F-mediated membrane fusion and presumably transsynaptic cell-to-cell transmission of the virus.
Protein Name Cell Adhesion Molecule 1
Immunoglobulin Superfamily Member 4
Igsf4
Nectin-Like Protein 2
Necl-2
Spermatogenic Immunoglobulin Superfamily
Sgigsf
Synaptic Cell Adhesion Molecule
Syncam
Tumor Suppressor In Lung Cancer 1
Tslc-1
Database Links Reactome: R-HSA-418990
Reactome: R-HSA-420597
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Synapse
Localized To The Basolateral Plasma Membrane Of Epithelial Cells In Gall Bladder
Alternative Protein Names Cell Adhesion Molecule 1 protein
Immunoglobulin Superfamily Member 4 protein
Igsf4 protein
Nectin-Like Protein 2 protein
Necl-2 protein
Spermatogenic Immunoglobulin Superfamily protein
Sgigsf protein
Synaptic Cell Adhesion Molecule protein
Syncam protein
Tumor Suppressor In Lung Cancer 1 protein
Tslc-1 protein
CADM1 protein
IGSF4 protein
IGSF4A protein
NECL2 protein
SYNCAM protein
TSLC1 protein

Information sourced from Uniprot.org