Human CADM1/IGSF4A protein (Recombinant) (C-His) (STJP001215)

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Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human CADM1/IGSF4A-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.

Formulation:

Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.

Gene Symbol:	CADM1
Gene ID:	23705
Uniprot ID:	CADM1_HUMAN
Immunogen:	Recombinant Human CADM1/IGSF4A Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln45-His374) of human CADM1/IGSF4A (Accession #NP_055148.3) fused with a 6×His tag at the C-terminus.

Function	Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. By interacting with CRTAM and thus promoting the adhesion between CD8+ T-cells and CD8+ dendritic cells, regulates the retention of activated CD8+ T-cell within the draining lymph node. Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells. Interaction with CRTAM promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. May contribute to the less invasive phenotypes of lepidic growth tumor cells.
Protein Name	Cell Adhesion Molecule 1 Immunoglobulin Superfamily Member 4 Igsf4 Nectin-Like Protein 2 Necl-2 Spermatogenic Immunoglobulin Superfamily Sgigsf Synaptic Cell Adhesion Molecule Syncam Tumor Suppressor In Lung Cancer 1 Tslc-1
Database Links	Reactome: R-HSA-418990 Reactome: R-HSA-420597
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Synapse Localized To The Basolateral Plasma Membrane Of Epithelial Cells In Gall Bladder
Alternative Protein Names	Cell Adhesion Molecule 1 protein Immunoglobulin Superfamily Member 4 protein Igsf4 protein Nectin-Like Protein 2 protein Necl-2 protein Spermatogenic Immunoglobulin Superfamily protein Sgigsf protein Synaptic Cell Adhesion Molecule protein Syncam protein Tumor Suppressor In Lung Cancer 1 protein Tslc-1 protein CADM1 protein IGSF4 protein IGSF4A protein NECL2 protein SYNCAM protein TSLC1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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