Human CACNA1A protein (Recombinant) (N-GST & C-His) (STJP008522)

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STJP008522
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Covered by St John's Laboratory Guarantee

Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CACNA1A-N-GST & C-His protein was developed from e. coli and has a target region of N-GST & C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CACNA1A
Gene ID: 773
Uniprot ID: CAC1A_HUMAN
Immunogen Region: Met249-Trp335
Immunogen: Homo sapiens (Human)
Function Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by the spider omega-agatoxin-IVA (AC P54282). They are however insensitive to dihydropyridines (DHP).
Protein Name Voltage-Dependent P/Q-Type Calcium Channel Subunit Alpha-1a
Brain Calcium Channel I
Bi
Calcium Channel - L Type - Alpha-1 Polypeptide Isoform 4
Voltage-Gated Calcium Channel Subunit Alpha Cav2.1
Database Links Reactome: R-HSA-112308
Reactome: R-HSA-422356
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Protein Names Voltage-Dependent P/Q-Type Calcium Channel Subunit Alpha-1a protein
Brain Calcium Channel I protein
Bi protein
Calcium Channel - L Type - Alpha-1 Polypeptide Isoform 4 protein
Voltage-Gated Calcium Channel Subunit Alpha Cav2.1 protein
CACNA1A protein
CACH4 protein
CACN3 protein
CACNL1A4 protein

Information sourced from Uniprot.org

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