| Host: | E.coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.2 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | CHLSN |
| Gene ID: | 84310 |
| Uniprot ID: | CHOLN_HUMAN |
| Immunogen Region: | Met1-Ser194 |
| Immunogen: | Recombinant Human C7orf50 (Cholesin) Protein is produced by E. coli cells expression system. The target protein is expressed with sequence (Met1-Ser194) of Human C7orf50 (Cholesin) (Accession #Q9BRJ6) fused with His tag at the C-terminus. |
| Immunogen Sequence: | MAKQKRKVPEVTEKKNKKLK KASAEGPLLGPEAAPSGEGA GSKGEAVLRPGLDAEPELSP EEQRVLERKLKKERKKEERQ RLREAGLVAQHPPARRSGAE LALDYLCRWAQKHKNWRFQK TRQTWLLLHMYDSDKVPDEH FSTLLAYLEGLQGRARELTV QKAEALMRELDEEGSDPPLP GRAQRIRQVLQLLS |
| Tissue Specificity | Secreted from the instestine, secretion is induced by feeding and cholesterol absorption. |
| Function | Hormone secreted from the intestine in response to cholesterol, where it acts to inhibit cholesterol synthesis in the liver and VLDL secretion,leading to a reduction in circulating cholesterol levels. Acts through binding to its receptor, GPR146. |
| Protein Name | Protein Cholesin |
| Database Links | |
| Cellular Localisation | SecretedSecreted Via ExosomesSecretion Is Induced By Feeding And Cholesterol Absorption |
| Alternative Protein Names | Protein Cholesin proteinCHLSN proteinC7orf50 proteinFP15621 protein |
Information sourced from Uniprot.org
