Function | mRNA-binding protein which interacts with a range of target mRNAs including SERPINE1, ACTA2, CCN2 and COL4A1 and may promote extracellular matrix production. Binds to the 3'-UTR of SERPINE1 mRNA and stabilizes the mRNA, possibly by competing for binding with SERBP1 and preventing SERBP1-mediated mRNA degradation. Also binds to the 3'-UTR of ACTA2. Testis-derived lumicrine factor that triggers epididymal differentiation and sperm maturation. |
Protein Name | Nell2-Interacting Cell Ontogeny Regulator 1Nell2-Interacting Cofactor For Lumicrine SignalingNicol |
Cellular Localisation | SecretedCytoplasmPerinuclear RegionDetected In The Perinuclear Region Of Fibroblasts |
Alternative Protein Names | Nell2-Interacting Cell Ontogeny Regulator 1 proteinNell2-Interacting Cofactor For Lumicrine Signaling proteinNicol proteinNICOL1 proteinC4orf48 protein |
Information sourced from Uniprot.org