| Function | Component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C1S is activated following association of the C1 complex with immunoglobulins (IgG or IgM) complexed with antigens to form antigen-antibody complexes on the surface of pathogens. C1S is cleaved and activated by C1R to generate C1s subcomponent heavy and light chains. C1s subcomponent light chain then cleaves and activates C2 and C4, the next components of the classical complement pathway. Complement C1s subcomponent light chain: Serine protease component of the complement C1 complex, which catalyzes cleavage and activation of C2 and C4, the next components of the classical complement pathway. Also able to cleave C1 inhibitor (SERPING1) in vitro.additional evidence is however required to confirm this result in vivo. Also cleaves IGFBP5 and thereby inhibits the trophic effects of IGF1. |
| Protein Name | Complement C1s SubcomponentC1 EsteraseComplement Component 1 Subcomponent S Cleaved Into - Complement C1s Subcomponent Heavy ChainComplement C1s Subcomponent Chain A - Complement C1s Subcomponent Light ChainComplement C1s Subcomponent Chain B |
| Database Links | Reactome: R-HSA-166663Reactome: R-HSA-173623Reactome: R-HSA-977606 |
| Cellular Localisation | SecretedCell SurfaceRecruited To The Surface Of Pathogens By The C1q Subcomplex |
| Alternative Protein Names | Complement C1s Subcomponent proteinC1 Esterase proteinComplement Component 1 Subcomponent S Cleaved Into - Complement C1s Subcomponent Heavy Chain proteinComplement C1s Subcomponent Chain A - Complement C1s Subcomponent Light Chain proteinComplement C1s Subcomponent Chain B proteinC1S protein |
Information sourced from Uniprot.org
