Human c-Kit ligand/SCF/KITLG protein (Recombinant) (C-His) (STJP002574)

SKU:
STJP002574

Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human c-Kit ligand/SCF/KITLG-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity: 1.Measured in a cell proliferation assay using TF-1 Human erythroleukemic cells. The ED50 for this effect is 0.08-0.3 ng/mL.2.Measured by its binding ability in a functional ELISA. Immobilized recombinant human SCF at 1 Mu g/mL (100 Mu L/well) can bi
Gene Symbol: KITLG
Gene ID: 4254
Uniprot ID: SCF_HUMAN
Immunogen Region: Glu26-His214
Immunogen: Recombinant Human c-Kit ligand/SCF/KITLG Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu26-His214) of human SCF/C-kit ligand (Accession #NP_000890.1) fused with a 6×His tag at the C-terminus.
Function Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
Protein Name Kit Ligand
Mast Cell Growth Factor
Mgf
Stem Cell Factor
Scf
C-Kit Ligand Cleaved Into - Soluble Kit Ligand
Skitlg
Database Links Reactome: R-HSA-1257604 P21583-1
Reactome: R-HSA-1433557 P21583-1
Reactome: R-HSA-1433559 P21583-1
Reactome: R-HSA-2219530 P21583-1
Reactome: R-HSA-5673001 P21583-1
Reactome: R-HSA-6811558 P21583-1
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Cytoplasm
Cytoplasm
Cytoskeleton
Cell Membrane
Cell Projection
Lamellipodium
Filopodium
Soluble Kit Ligand: Secreted
Alternative Protein Names Kit Ligand protein
Mast Cell Growth Factor protein
Mgf protein
Stem Cell Factor protein
Scf protein
C-Kit Ligand Cleaved Into - Soluble Kit Ligand protein
Skitlg protein
KITLG protein
MGF protein
SCF protein

Information sourced from Uniprot.org

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