| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.2 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
<0.1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: |
CD160 |
| Gene ID: |
11126 |
| Uniprot ID: |
BY55_HUMAN |
| Immunogen Region: |
Ile27-Ser159 |
| Immunogen: |
Recombinant Human CD160 Protein is produced by Human cells expression system. The target protein is expressed with sequence (Ile27-Ser159) of human CD160 (Accession #O95971) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: |
INITSSASQEGTRLNLICTV WHKKEEAEGFVVFLCKDRSG DCSPETSLKQLRLKRDPGID GVGEISSQLMFTISQVTPLH SGTYQCCARSQKSGIRLQGH FFSILFTETGNYTVTGLKQR QHLEFSHNEGTLS |
| Function | CD160 antigen: Receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation. Exists as a GPI-anchored and as a transmembrane form, each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells. Receptor for both classical and non-classical MHC class I molecules. In the context of acute viral infection, recognizes HLA-C and triggers NK cell cytotoxic activity, likely playing a role in anti-viral innate immune response. On CD8+ T cells, binds HLA-A2-B2M in complex with a viral peptide and provides a costimulatory signal to activated/memory T cells. Upon persistent antigen stimulation, such as occurs during chronic viral infection, may progressively inhibit TCR signaling in memory CD8+ T cells, contributing to T cell exhaustion. On endothelial cells, recognizes HLA-G and controls angiogenesis in immune privileged sites. Receptor or ligand for TNF superfamily member TNFRSF14, participating in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. Upon ligation of TNFRSF14, provides stimulatory signal to NK cells enhancing IFNG production and anti-tumor immune response. On activated CD4+ T cells, interacts with TNFRSF14 and down-regulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response. In the context of bacterial infection, acts as a ligand for TNFRSF14 on epithelial cells, triggering the production of antimicrobial proteins and pro-inflammatory cytokines. CD160 antigen, soluble form: The soluble GPI-cleaved form, usually released by activated lymphocytes, might play an immune regulatory role by limiting lymphocyte effector functions. |
| Protein Name | Cd160 AntigenNatural Killer Cell Receptor By55Cd Antigen Cd160 Cleaved Into - Cd160 Antigen - Soluble Form |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cd160 Antigen: Cell MembraneLipid-AnchorGpi-AnchorCd160 AntigenSoluble Form: SecretedReleased From The Cell Membrane By Gpi Cleavage |
| Alternative Protein Names | Cd160 Antigen proteinNatural Killer Cell Receptor By55 proteinCd Antigen Cd160 Cleaved Into - Cd160 Antigen - Soluble Form proteinCD160 proteinBY55 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
