• Human BTLA protein (Active Recombinant) (C-hFc&His) (STJP001130)
  • Human BTLA protein (Active Recombinant) (C-hFc&His) (STJP001130)
  • Human BTLA protein (Active Recombinant) (C-hFc&His) (STJP001130)
  • Human BTLA protein (Active Recombinant) (C-hFc&His) (STJP001130)

Human BTLA protein (Active Recombinant) (C-hFc&His) (STJP001130)

SKU:
STJP001130

£76.50 - £248.50
Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Active Recombinant-Human BTLA-C-hFc&His protein was developed from hek293 cells and has a target region of C-hFc&His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Recombinant human BTLA at 3 Mu g/mL (100 Mu L/well) can bind Biotinylated Recombinant human HVEM with a linear range of 18-72 ng/mL.
Gene Symbol: BTLA
Gene ID: 151888
Uniprot ID: BTLA_HUMAN
Immunogen Region: Lys31-Thr134
Immunogen: Active Recombinant Human BTLA Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Lys31-Thr134) of human BTLA (Accession #NP_001078826.1.) fused with an Fc, 6×His tag at the C-terminus.
Post Translational Modifications Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with PTPN6 and PTPN11. N-glycosylated.
Function Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells.
Protein Name B- And T-Lymphocyte Attenuator
B- And T-Lymphocyte-Associated Protein
Cd Antigen Cd272
Database Links Reactome: R-HSA-388841
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names B- And T-Lymphocyte Attenuator protein
B- And T-Lymphocyte-Associated Protein protein
Cd Antigen Cd272 protein
BTLA protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance