| Function | Chromatin reader that recognizes and binds acetylated histones, thereby controlling gene expression and remodeling chromatin structures. Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation. In vitro, binds acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4. Involved in endoderm differentiation via its association with long non-coding RNA (lncRNA) DIGIT: BRD3 undergoes liquid-liquid phase separation upon binding to lncRNA DIGIT, promoting binding to histone H3 acetylated at 'Lys-18' (H3K18ac) to induce endoderm gene expression. Also binds non-histones acetylated proteins, such as GATA1 and GATA2: regulates transcription by promoting the binding of the transcription factor GATA1 to its targets. |
| Protein Name | Bromodomain-Containing Protein 3Ring3-Like Protein |
| Cellular Localisation | NucleusChromosomeDetected On Chromatin |
| Alternative Protein Names | Bromodomain-Containing Protein 3 proteinRing3-Like Protein proteinBRD3 proteinKIAA0043 proteinRING3L protein |
Information sourced from Uniprot.org
