Human BMP4 (Active) protein (Recombinant-Active) (STJP012467)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human BMP4 (Active)-protein was developed from e.coli. For use in research applications. |
| Applications | ELISA/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Supplied as a 0.2 Mu m filtered solution of 4mM HCl. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at ≤-80°C, stable for 1 year after receipt. Store at ≤-80°C, stable for 3 months under sterile conditions after opening. |
| Endotoxin | < 0.01 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | BMP4 |
| Gene ID | 652 |
| Uniprot ID | BMP4_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser293-Arg408 |
Additional Info
| Function | Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Positively regulates the expression of odontogenic development regulator MSX1 via inducing the IPO7-mediated import of SMAD1 to the nucleus. Required for MSX1-mediated mesenchymal molar tooth bud development beyond the bud stage, via promoting Wnt signaling. Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling. Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway. Can also signal through non-canonical BMP pathways such as ERK/MAP kinase, PI3K/Akt, or SRC cascades. For example, induces SRC phosphorylation which, in turn, activates VEGFR2, leading to an angiogenic response. |
| Protein Name | Bone Morphogenetic Protein 4Bmp-4Bone Morphogenetic Protein 2bBmp-2b |
| Database Links | Reactome: R-HSA-2129379Reactome: R-HSA-381426Reactome: R-HSA-8957275Reactome: R-HSA-9754189Reactome: R-HSA-9758920Reactome: R-HSA-9761174Reactome: R-HSA-9793380Reactome: R-HSA-9827857Reactome: R-HSA-9830364Reactome: R-HSA-9830674Reactome: R-HSA-9834899 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Protein Names | Bone Morphogenetic Protein 4 proteinBmp-4 proteinBone Morphogenetic Protein 2b proteinBmp-2b proteinBMP4 proteinBMP2B proteinDVR4 protein |
Information sourced from Uniprot.org