SDS-PAGE of recombinant human BMP-14 GDF-5 protein under reducing conditions

Human BMP-14/GDF-5 protein (Recombinant) (His-Tag) (STJP016479)

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STJP016479
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Short Description :Recombinant-Human BMP-14/GDF-5-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.5 mg/mL
Formulation:Liquid in 10mM Sodium Citrate buffer (pH 3.5) containing 10% Glycerol
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Endotoxin:< 1 EU per 1ug of protein (determined by LAL method)
Gene Symbol:GDF5
Gene ID:8200
Uniprot ID:GDF5_HUMAN
Accession Number:NP_000548
Immunogen:Human
Immunogen Region:382-501aa
Immunogen Sequence: MAPLATRQGK RPSKNLKARC SRKALHVNFK DMGWDDWIIA PLEYEAFHCE GLCEFPLRSH LEPTNHAVIQ TLMNSMDPES TPPTCCVPTR LSPISILFID SANNVVYKQY EDMVVESCGC R
Tissue Specificity Predominantly expressed in long bones during embryonic development. Expressed in monocytes (at protein level).
Function Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction. Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG. Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes.
Protein Name Growth/Differentiation Factor 5
Gdf-5
Bone Morphogenetic Protein 14
Bmp-14
Cartilage-Derived Morphogenetic Protein 1
Cdmp-1
Lipopolysaccharide-Associated Protein 4
Lap-4
Lps-Associated Protein 4
Radotermin
Database Links Reactome: R-HSA-2129379
Cellular Localisation Secreted
Cell Membrane
Alternative Protein Names Growth/Differentiation Factor 5 protein
Gdf-5 protein
Bone Morphogenetic Protein 14 protein
Bmp-14 protein
Cartilage-Derived Morphogenetic Protein 1 protein
Cdmp-1 protein
Lipopolysaccharide-Associated Protein 4 protein
Lap-4 protein
Lps-Associated Protein 4 protein
Radotermin protein
GDF5 protein
BMP14 protein
CDMP1 protein

Information sourced from Uniprot.org

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