| Tissue Specificity | Expressed in B-cell lineage and fibroblast cell lines (at protein level). Highest levels of expression in the spleen, with lower levels in the liver, kidney, pancreas, small intestines and colon. |
| Post Translational Modifications | Following BCR activation, phosphorylated on tyrosine residues by SYK and LYN. When phosphorylated, serves as a scaffold to assemble downstream targets of antigen activation, including PLCG1, VAV1, GRB2 and NCK1. Phosphorylation of Tyr-84, Tyr-178 and Tyr-189 facilitates PLCG1 binding. Phosphorylation of Tyr-96 facilitates BTK binding. Phosphorylation of Tyr-72 facilitates VAV1 and NCK1 binding. Phosphorylation is required for both Ca(2+) and MAPK signaling pathways. |
| Function | Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis. |
| Protein Name | B-Cell Linker ProteinB-Cell Adapter Containing A Sh2 Domain ProteinB-Cell Adapter Containing A Src Homology 2 Domain ProteinCytoplasmic Adapter ProteinSrc Homology 2 Domain-Containing Leukocyte Protein Of 65 KdaSlp-65 |
| Database Links | Reactome: R-HSA-912631Reactome: R-HSA-9679191Reactome: R-HSA-983695 |
| Cellular Localisation | CytoplasmCell MembraneBcr Activation Results In The Translocation To Membrane Fraction |
| Alternative Protein Names | B-Cell Linker Protein proteinB-Cell Adapter Containing A Sh2 Domain Protein proteinB-Cell Adapter Containing A Src Homology 2 Domain Protein proteinCytoplasmic Adapter Protein proteinSrc Homology 2 Domain-Containing Leukocyte Protein Of 65 Kda proteinSlp-65 proteinBLNK proteinBASH proteinSLP65 protein |
Information sourced from Uniprot.org
