| Post Translational Modifications | Auto-ubiquitinated and degraded by the proteasome in apoptotic cells. Upon stimulation of death receptors, including TNFRSF10B, recruited to receptors and cleaved by caspases. Proteolytic fragments remain associated with the receptors. This cleavage presumably inactivates the protein. |
| Function | Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle. |
| Protein Name | Baculoviral Iap Repeat-Containing Protein 2Cellular Inhibitor Of Apoptosis 1C-Iap1Iap Homolog BInhibitor Of Apoptosis Protein 2Hiap-2Hiap2Ring Finger Protein 48Ring-Type E3 Ubiquitin Transferase Birc2Tnfr2-Traf-Signaling Complex Protein 2 |
| Database Links | Reactome: R-HSA-111465Reactome: R-HSA-168638Reactome: R-HSA-168927Reactome: R-HSA-5213460Reactome: R-HSA-5357786Reactome: R-HSA-5357905Reactome: R-HSA-5357956Reactome: R-HSA-5668541Reactome: R-HSA-5675482Reactome: R-HSA-5676594Reactome: R-HSA-5689880Reactome: R-HSA-937041 |
| Cellular Localisation | CytoplasmNucleusAgents That Induce Either The Extrinsic Or Intrinsic Apoptotic Pathways Promote Its Redistribution From The Nuclear Compartment To The Cytoplasmic CompartmentAssociated With The Midbody In Telophase CellsAnd Found Diffusely In The Nucleus Of Interphase Cells |
| Alternative Protein Names | Baculoviral Iap Repeat-Containing Protein 2 proteinCellular Inhibitor Of Apoptosis 1 proteinC-Iap1 proteinIap Homolog B proteinInhibitor Of Apoptosis Protein 2 proteinHiap-2 proteinHiap2 proteinRing Finger Protein 48 proteinRing-Type E3 Ubiquitin Transferase Birc2 proteinTnfr2-Traf-Signaling Complex Protein 2 proteinBIRC2 proteinAPI1 proteinMIHB proteinRNF48 protein |
Information sourced from Uniprot.org
