Human BID protein (Recombinant) (Tag free) (STJP014546)

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STJP014546-100
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Short Description :Recombinant-Human BID-Tag free protein was developed from e.coli and has a target region of Tag free. For use in research applications.
Applications:ELISA/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Unconjugated
Formulation:Supplied as a 0.22 Mu m filtered solution in 20mM PB, 100mM KCl, pH 7.4.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin:< 1 EU/µg as determined by LAL test.
Gene Symbol:BID
Gene ID:637
Uniprot ID:BID_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Met1-Asp195
Post Translational Modifications BH3-interacting domain death agonist: TNF-alpha induces caspase-mediated cleavage into a major p15 and minor p13 and p11 products. Cleaved by CASP6 into a major p15 and minor p13 products, leading to release of cytochrome c and subsequent nonalcoholic steatohepatitis. BH3-interacting domain death agonist p15: Ubiquitinated by ITCH.ubiquitination results in proteasome-dependent degradation.
Function Induces caspases and apoptosis. Counters the protective effect of BCL2. BH3-interacting domain death agonist p15: Induces caspase activation and apoptosis. Allows the release of cytochrome c. Isoform 1: Induces ICE-like proteases and apoptosis. Isoform 2: Induces ICE-like proteases and apoptosis. Isoform 3: Does not induce apoptosis. Isoform 4: Induces ICE-like proteases and apoptosis.
Protein Name Bh3-Interacting Domain Death Agonist
P22 Bid
Bid Cleaved Into - Bh3-Interacting Domain Death Agonist P15
P15 Bid - Bh3-Interacting Domain Death Agonist P13
P13 Bid - Bh3-Interacting Domain Death Agonist P11
P11 Bid
Database Links Reactome: R-HSA-111447
Reactome: R-HSA-111452
Reactome: R-HSA-111453
Reactome: R-HSA-114294
Reactome: R-HSA-6803204
Reactome: R-HSA-75108
Cellular Localisation Cytoplasm
Mitochondrion Membrane
Mitochondrion Outer Membrane
When Uncleaved
It Is Predominantly Cytoplasmic
Bh3-Interacting Domain Death Agonist P15: Mitochondrion Membrane
Translocates To Mitochondria As An Integral Membrane Protein
Bh3-Interacting Domain Death Agonist P13: Mitochondrion Membrane
Associated With The Mitochondrial Membrane
Isoform 1: Cytoplasm
Isoform 3: Cytoplasm
Isoform 2: Mitochondrion Membrane
A Significant Proportion Of Isoform 2 Localizes To Mitochondria
It May Be Cleaved Constitutively
Alternative Protein Names Bh3-Interacting Domain Death Agonist protein
P22 Bid protein
Bid Cleaved Into - Bh3-Interacting Domain Death Agonist P15 protein
P15 Bid - Bh3-Interacting Domain Death Agonist P13 protein
P13 Bid - Bh3-Interacting Domain Death Agonist P11 protein
P11 Bid protein
BID protein

Information sourced from Uniprot.org

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