Human BCOR protein (Recombinant) (N-His) (STJP006385)

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STJP006385
£328.50 - £1,437.50
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human BCOR-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: BCOR
Gene ID: 54880
Uniprot ID: BCOR_HUMAN
Immunogen Region: Met1569-Trp1755
Immunogen: Homo sapiens (Human)
Function Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A.impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells.the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).
Protein Name Bcl-6 Corepressor
Bcor
Cellular Localisation Nucleus
Alternative Protein Names Bcl-6 Corepressor protein
Bcor protein
BCOR protein
KIAA1575 protein

Information sourced from Uniprot.org

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