Human BCMA (CD269) protein (Recombinant) (STJP000587)
SPECIFICATIONS
HostHEK293
ConjugationUnconjugated
ImmunogenOptimized DNA sequence encoding Human BCMA extracellular domain sp|Q02223|1-54 fused to C terminal Human IgG1 Fc His tag was expressed in HEK293 Cells. NA
General Information
| Short Description | Recombinant-Human BCMA (CD269)-protein was developed from hek293. For use in research applications. |
| Host | HEK293 |
| Note | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers. |
| Formulation | Lyophilised from 0.2 Mu m filtered mm Tris solution pH7.5. |
| Storage Instruction | Can be stored in working aliquots atΒ°C-Β°C C for one month, or at-20Β°C C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. NA |
| Endotoxin | Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than.1 ng/Β΅g (1EU/Β΅g). NA |
| Immunoreactivity | The ED (50) was determined by the ability to bind immobilized recombinant Human BAFF and was calculated to beng/ml. NA |
Target Information
| Gene Symbol | TNFRSF17 |
| Gene ID | 608 |
| Uniprot ID | TNR17_HUMAN |
| Immunogen | Optimized DNA sequence encoding Human BCMA extracellular domain sp|Q02223|1-54 fused to C terminal Human IgG1 Fc His tag was expressed in HEK293 Cells. NA |
| Immunogen Region | ECD |
| Immunogen Sequence | MLQMAGQCSQ NEYFDSLLHA CIPCQLRCSS NTPPLTCQRY CNASVTNSVK GTNA ILWTCL NA |
Additional Info
| Tissue Specificity | Expressed in mature B-cells, but not in T-cells or monocytes. |
| Function | Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 17B-Cell Maturation ProteinCd Antigen Cd269 |
| Database Links | Reactome: R-HSA-5669034 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Iii Membrane ProteinEndomembrane SystemPerinuclear Golgi-Like Structures |
| Alternative Protein Names | Tumor Necrosis Factor Receptor Superfamily Member 17 proteinB-Cell Maturation Protein proteinCd Antigen Cd269 proteinTNFRSF17 proteinBCM proteinBCMA protein |
Information sourced from Uniprot.org