Human BAFF/CD257 (Tumor Necrosis Factor Ligand Superfamily Member 13b) Antibody Pair (STJAP00477)
General Information
| Short Description | This BAFF/CD257 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Applications | ELISA |
| Host | Goat/Goat |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated/Biotin |
| Concentration | 0.5 mg/mL |
| Purification | Capture Purification: Antigen Affinity.Detection Purification: Antigen Affinity. |
| Formulation | Capture Buffer: PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5.Detection Buffer: PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5. |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
| Determination Method | Colormetric |
Target Information
| Gene Symbol | TNFSF13B |
| Gene ID | 10673 |
| Uniprot ID | TN13B_HUMAN |
| Immunogen | Capture immunogen: Recombinant Human BAFF/CD257 protien.Detection Immunogen: Recombinant Human BAFF/CD257 protien. |
| Sample Type | Serum, plasma and other biological fluids |
Additional Info
| Post Translational Modifications | The soluble form derives from the membrane form by proteolytic processing. Isoform 2 is not efficiently shed from the membrane unlike isoform 1. N-glycosylated. |
| Function | Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis. |
| Protein Name | Tumor Necrosis Factor Ligand Superfamily Member 13bB Lymphocyte StimulatorBlysB-Cell-Activating FactorBaffDendritic Cell-Derived Tnf-Like MoleculeTnf- And Apol-Related Leukocyte Expressed Ligand 1Tall-1Cd Antigen Cd257 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 13b - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 13b - Soluble Form |
| Database Links | Reactome: R-HSA-5668541Reactome: R-HSA-5669034Reactome: R-HSA-5676594 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinTumor Necrosis Factor Ligand Superfamily Member 13bSoluble Form: Secreted |
| Alternative Antibody Pair Names | Tumor Necrosis Factor Ligand Superfamily Member 13b antibody pairB Lymphocyte Stimulator antibody pairBlys antibody pairB-Cell-Activating Factor antibody pairBaff antibody pairDendritic Cell-Derived Tnf-Like Molecule antibody pairTnf- And Apol-Related Leukocyte Expressed Ligand 1 antibody pairTall-1 antibody pairCd Antigen Cd257 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 13b - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 13b - Soluble Form antibody pairTNFSF13B antibody pairBAFF antibody pairBLYS antibody pairTALL1 antibody pairTNFSF20 antibody pairZTNF4 antibody pairUNQ401 antibody pairPRO738 antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Human BAFF/CD257 (Tumor Necrosis Factor Ligand Superfamily Member 13b) Antibody Pair (STJAP00477)
This antibody pair detects human BAFF/CD257, also known as Tumor Necrosis Factor Ligand Superfamily Member 13b (UniProt Q9Y275). Reactivity is confirmed for human samples only.
The capture antibody is supplied unconjugated and the detection antibody is biotin-conjugated; both are provided at 0.5 mg/mL. Both antibodies are goat-raised and purified by antigen affinity.
This antibody pair has been validated for use in ELISA. Suitable sample types include serum, plasma, and other biological fluids.
The capture antibody is formulated in PBS with 0.04% Proclin 300 and 50% glycerol at pH 7.5. The detection antibody is formulated in PBS with 0.04% Proclin 300, 1% protective protein, and 50% glycerol at pH 7.5.
Both components should be stored at -20°C for long-term storage. Freeze-thaw cycles should be avoided to maintain antibody integrity.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.