Human B7-H5/Gi24/VISTA protein (Recombinant) (C-His) (STJP001028)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human B7-H5/Gi24/VISTA Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Phe 33-Ala 194 ) of human VISTA/B7-H5/PD-1H (Accession #AAH20568.1) fused with a 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human B7-H5/Gi24/VISTA-C-His protein was developed in hek293 cells using the region Phe 33-Ala 194. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | VSIR |
| Gene ID | 64115 |
| Uniprot ID | VISTA_HUMAN |
| Immunogen | Recombinant Human B7-H5/Gi24/VISTA Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Phe 33-Ala 194 ) of human VISTA/B7-H5/PD-1H (Accession #AAH20568.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Region | Phe 33-Ala 194 |
| Immunogen Sequence | FKVATPYSLYVCPEGQNVTL TCRLLGPVDKGHDVTFYKTW YRSSRGEVQTCSERRPIRNL TFQDLHLHHGGHQAANTSHD LAQRHGLESASDHHGNFSIT MRNLTLLDSGLYCCLVVEIR HHHSEHRVHGAMELQVQTGK DAPSNCVVYPSSSQESENIT AA |
Additional Info
| Post Translational Modifications | At the cell surface, may be cleaved by MMP14. N-glycosylated. |
| Function | Immunoregulatory receptor which inhibits the T-cell response. May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling. May stimulate MMP14-mediated MMP2 activation. |
| Protein Name | V-Type Immunoglobulin Domain-Containing Suppressor Of T-Cell ActivationPlatelet Receptor Gi24Stress-Induced Secreted Protein-1Sisp-1V-Set Domain-Containing Immunoregulatory ReceptorV-Set Immunoregulatory Receptor |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | V-Type Immunoglobulin Domain-Containing Suppressor Of T-Cell Activation proteinPlatelet Receptor Gi24 proteinStress-Induced Secreted Protein-1 proteinSisp-1 proteinV-Set Domain-Containing Immunoregulatory Receptor proteinV-Set Immunoregulatory Receptor proteinVSIR proteinC10orf54 proteinSISP1 proteinVISTA proteinPP2135 proteinUNQ730 proteinPRO1412 protein |
Information sourced from Uniprot.org