• Biotinylated Human B7-H4 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
  • The purity of Biotinylated Human B7-H4 is greater than 95% as determined by SEC-HPLC.
  • Immobilized Anti-B7-H4 Antibody, hFc Tag at 1 Mu g/ml (100 Mu l/well) on the plate. Dose response curve for Biotinylated Human B7-H4, His Tag with the EC50 of 24. 3ng/ml determined by ELISA.

Human B7-H4 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001663)

SKU:
STJP001663

£618.50 - £1,909.50
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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human B7-H4-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range: Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction: The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol: VTCN1
Gene ID: 79679
Uniprot ID: VTCN1_HUMAN
Immunogen Region: Phe29-Ala258
Immunogen: DNA sequence encoding Human B7-H4 including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Post Translational Modifications N-glycosylated.
Function Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.
Protein Name V-Set Domain-Containing T-Cell Activation Inhibitor 1
B7 Homolog 4
B7-H4
B7h.5
Immune Costimulatory Protein B7-H4
Protein B7s1
T-Cell Costimulatory Molecule B7x
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Expressed At The Cell Surface
A Soluble Form Has Also Been Detected
Alternative Protein Names V-Set Domain-Containing T-Cell Activation Inhibitor 1 protein
B7 Homolog 4 protein
B7-H4 protein
B7h.5 protein
Immune Costimulatory Protein B7-H4 protein
Protein B7s1 protein
T-Cell Costimulatory Molecule B7x protein
VTCN1 protein
B7H4 protein
UNQ659 protein
PRO1291 protein

Information sourced from Uniprot.org

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