Human B4GAT1 protein (Recombinant) (C-His) (STJP012984)

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STJP012984-100
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Host: Mammalian Cells
Applications: ELISA/WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human B4GAT1-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Conjugation: Unconjugated
Formulation: Lyophilized from a 0.22 Mu m filtered solution in 20mM Tris-HCl, 150mM NaCl, pH 7.4.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: < 1 EU/µg as determined by LAL test.
Gene Symbol: B4GAT1
Gene ID: 11041
Uniprot ID: B4GA1_HUMAN
Immunogen Region: Asp43-Cys415
Immunogen: Homo sapiens (Human)
Function Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE1, during synthesis of phosphorylated O-mannosyl glycan. Phosphorylated O-mannosyl glycan is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Required for axon guidance.via its function in O-mannosylation of alpha-dystroglycan (DAG1).
Protein Name Beta-1 -4-Glucuronyltransferase 1
I-Beta-1 -3-N-Acetylglucosaminyltransferase
Ignt
N-Acetyllactosaminide Beta-1 -3-N-Acetylglucosaminyltransferase
Poly-N-Acetyllactosamine Extension Enzyme
Udp-Glcnac -Betagal Beta-1 -3-N-Acetylglucosaminyltransferase 1
Database Links Reactome: R-HSA-2022854
Reactome: R-HSA-5083627
Reactome: R-HSA-5173105
Cellular Localisation Golgi Apparatus Membrane
Single-Pass Type Ii Membrane Protein
Localizes Near The Trans-Golgi Apparatus
Alternative Protein Names Beta-1 -4-Glucuronyltransferase 1 protein
I-Beta-1 -3-N-Acetylglucosaminyltransferase protein
Ignt protein
N-Acetyllactosaminide Beta-1 -3-N-Acetylglucosaminyltransferase protein
Poly-N-Acetyllactosamine Extension Enzyme protein
Udp-Glcnac -Betagal Beta-1 -3-N-Acetylglucosaminyltransferase 1 protein
B4GAT1 protein
B3GNT1 protein
B3GNT6 protein

Information sourced from Uniprot.org