| Post Translational Modifications | N-glycosylated. |
| Function | Galactose (Gal) transferase involved in the synthesis of terminal N-acetyllactosamine (LacNac) unit present on glycan chains of glycoproteins and glycosphingolipids. Catalyzes the transfer of Gal residue via a beta1->4 linkage from UDP-Gal to the non-reducing terminal N-acetyl glucosamine 6-O-sulfate (6-O-sulfoGlcNAc) in the linearly growing chain of both N- and O-linked keratan sulfate proteoglycans. Cooperates with B3GNT7 N-acetyl glucosamine transferase and CHST6 and CHST1 sulfotransferases to construct and elongate mono- and disulfated disaccharide units ->3Galbeta1->4(6-sulfoGlcNAcbeta)1-> and ->3(6-sulfoGalbeta)1->4(6-sulfoGlcNAcbeta)1-> within keratan sulfate polymer. Transfers Gal residue via a beta1->4 linkage to terminal 6-O-sulfoGlcNAc within the LacNac unit of core 2 O-glycans forming 6-sulfo-sialyl-Lewis X (sLex). May contribute to the generation of sLex epitope on mucin-type glycoproteins that serve as ligands for SELL/L-selectin, a major regulator of leukocyte migration. In the biosynthesis pathway of neolacto-series glycosphingolipids, transfers Gal residue via a beta1->4 linkage to terminal GlcNAc of a lactotriaosylceramide (Lc3Cer) acceptor to form a neolactotetraosylceramide. |
| Protein Name | Beta-1 -4-Galactosyltransferase 4Beta-1 -4-Galtase 4Beta4gal-T4B4gal-T4Beta-N-Acetylglucosaminyl-Glycolipid Beta-1 -4-GalactosyltransferaseLactotriaosylceramide Beta-1 -4-GalactosyltransferaseN-Acetyllactosamine SynthaseNal SynthaseUdp-Gal -Beta-Glcnac Beta-1 -4-Galactosyltransferase 4Udp-Galactose -Beta-N-Acetylglucosamine Beta-1 -4-Galactosyltransferase 4 |
| Database Links | Reactome: R-HSA-2022854Reactome: R-HSA-975577 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane ProteinSecreted |
| Alternative Protein Names | Beta-1 -4-Galactosyltransferase 4 proteinBeta-1 -4-Galtase 4 proteinBeta4gal-T4 proteinB4gal-T4 proteinBeta-N-Acetylglucosaminyl-Glycolipid Beta-1 -4-Galactosyltransferase proteinLactotriaosylceramide Beta-1 -4-Galactosyltransferase proteinN-Acetyllactosamine Synthase proteinNal Synthase proteinUdp-Gal -Beta-Glcnac Beta-1 -4-Galactosyltransferase 4 proteinUdp-Galactose -Beta-N-Acetylglucosamine Beta-1 -4-Galactosyltransferase 4 proteinB4GALT4 proteinUNQ552 proteinPRO1109 protein |
Information sourced from Uniprot.org
