Human B3GAT3 protein (Recombinant) (N-His) (STJP003406)

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STJP003406
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human B3GAT3-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: B3GAT3
Gene ID: 26229
Uniprot ID: B3GA3_HUMAN
Immunogen Region: Leu74-Val335
Immunogen: Homo sapiens (Human)
Post Translational Modifications N-glycosylated.
Function Glycosaminoglycans biosynthesis. Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins. Shows strict specificity for Gal-beta-1,3-Gal-beta-1,4-Xyl, exhibiting negligible incorporation into other galactoside substrates including Galbeta1-3Gal beta1-O-benzyl, Galbeta1-4GlcNAc and Galbeta1-4Glc. Stimulates 2-phosphoxylose phosphatase activity of PXYLP1 in presence of uridine diphosphate-glucuronic acid (UDP-GlcUA) during completion of linkage region formation.
Protein Name Galactosylgalactosylxylosylprotein 3-Beta-Glucuronosyltransferase 3
Beta-1 -3-Glucuronyltransferase 3
Glucuronosyltransferase I
Glcat-I
Udp-Glcua -Gal Beta-1 -3-Gal-R Glucuronyltransferase
Glcuat-I
Database Links Reactome: R-HSA-1971475
Reactome: R-HSA-3560801
Cellular Localisation Golgi Apparatus Membrane
Single-Pass Type Ii Membrane Protein
Golgi Apparatus
Cis-Golgi Network
Alternative Protein Names Galactosylgalactosylxylosylprotein 3-Beta-Glucuronosyltransferase 3 protein
Beta-1 -3-Glucuronyltransferase 3 protein
Glucuronosyltransferase I protein
Glcat-I protein
Udp-Glcua -Gal Beta-1 -3-Gal-R Glucuronyltransferase protein
Glcuat-I protein
B3GAT3 protein

Information sourced from Uniprot.org

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