| Function | This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria.this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G. |
| Protein Name | AzurocidinCationic Antimicrobial Protein Cap37Heparin-Binding ProteinHbpHhbp |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Cytoplasmic Granule MembranePeripheral Membrane ProteinCytoplasmic SideLocalizes To Azurophil Granules Of Neutrophil GranulocytesAlso Called Primary GranulesThese Specialized Lysosomes Of The Neutrophil Formed Early During Promyelocyte Development Store Antibacterial Proteins And Peptides |
| Alternative Protein Names | Azurocidin proteinCationic Antimicrobial Protein Cap37 proteinHeparin-Binding Protein proteinHbp proteinHhbp proteinAZU1 protein |
Information sourced from Uniprot.org
