| Function | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones.it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B. As a consequence, the complex mediates transcriptional activation. In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1. |
| Protein Name | Autism Susceptibility Gene 2 Protein |
| Database Links | Reactome: R-HSA-8939243 |
| Cellular Localisation | NucleusCytoplasmCytoskeletonCell ProjectionGrowth ConeDetected Both In Cytoplasm And NucleusColocalizes With Rac1 At Actin-Rich Growth ConesDetected On The Promoter Region Of Actively Transcribed Genes |
| Alternative Protein Names | Autism Susceptibility Gene 2 Protein proteinAUTS2 proteinKIAA0442 protein |
Information sourced from Uniprot.org
