| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.056ng/mL |
| Detection Limit: | 0.156-10ng/mL |
| Short Description : | This ATP7b Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates or other biological fluids.. |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
| Gene Symbol: | ATP7B |
| Gene ID: | 540 |
| Uniprot ID: | ATP7B_HUMAN |
| Sample Type: | tissue homogenates or other biological fluids. |
| Tissue Specificity | Most abundant in liver and kidney and also found in brain. Isoform 2 is expressed in brain but not in liver. The cleaved form WND/140 kDa is found in liver cell lines and other tissues. |
| Post Translational Modifications | Isoform 1 may be proteolytically cleaved at the N-terminus to produce the WND/140 kDa form. |
| Function | Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload. |
| Protein Name | Copper-Transporting Atpase 2 Copper Pump 2 Wilson Disease-Associated Protein Cleaved Into - Wnd/140 Kda |
| Database Links | Reactome: R-HSA-936837 |
| Cellular Localisation | Golgi Apparatus Trans-Golgi Network Membrane Multi-Pass Membrane Protein Late Endosome Predominantly Found In The Trans-Golgi Network (Tgn) Localized In The Trans-Golgi Network Under Low Copper Conditions Redistributes To Cytoplasmic Vesicles When Cells Are Exposed To Elevated Copper Levels And Then Recycles Back To The Trans-Golgi Network When Copper Is Removed Isoform 1: Golgi Apparatus Membrane Isoform 2: Cytoplasm Wnd/140 Kda: Mitochondrion |
| Alternative ELISA Names | Copper-Transporting Atpase 2 ELISA kit Copper Pump 2 ELISA kit Wilson Disease-Associated Protein Cleaved Into - Wnd/140 Kda ELISA kit ATP7B ELISA kit PWD ELISA kit WC1 ELISA kit WND ELISA kit |
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Information sourced from Uniprot.org