| Function | Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. |
| Protein Name | V-Type Proton Atpase Subunit G 1V-Atpase Subunit G 1V-Atpase 13 Kda Subunit 1Vacuolar Proton Pump Subunit G 1Vacuolar Proton Pump Subunit M16 |
| Database Links | Reactome: R-HSA-1222556Reactome: R-HSA-77387Reactome: R-HSA-917977Reactome: R-HSA-9639288Reactome: R-HSA-983712Reactome: R-HSA-9857377 |
| Cellular Localisation | Apical Cell Membrane |
| Alternative Protein Names | V-Type Proton Atpase Subunit G 1 proteinV-Atpase Subunit G 1 proteinV-Atpase 13 Kda Subunit 1 proteinVacuolar Proton Pump Subunit G 1 proteinVacuolar Proton Pump Subunit M16 proteinATP6V1G1 proteinATP6G proteinATP6G1 proteinATP6J protein |
Information sourced from Uniprot.org
