| Function | Plays an essential role in both canonical and non-canonical autophagy: interacts with ATG12-ATG5 to mediate the lipidation to ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, GABARAPL2 and GABARAP). Acts as a molecular hub, coordinating autophagy pathways via distinct domains that support either canonical or non-canonical signaling. During canonical autophagy, interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to ATG8 proteins, to produce a membrane-bound activated form of ATG8. Thereby, controls the elongation of the nascent autophagosomal membrane. As part of the ATG8 conjugation system with ATG5 and ATG12, required for recruitment of LRRK2 to stressed lysosomes and induction of LRRK2 kinase activity in response to lysosomal stress. Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, probably by catalyzing conjugation of phosphatidylserine (PS) to ATG8. Non-canonical autophagy plays a key role in epithelial cells to limit lethal infection by influenza A (IAV) virus. Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production. Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response. Instead, promotes an autophagy-dependent antibacterial pathway together with NOD1 or NOD2. Plays a role in regulating morphology and function of Paneth cell. |
| Protein Name | Autophagy-Related Protein 16-1Apg16-Like 1 |
| Database Links | Reactome: R-HSA-1632852 |
| Cellular Localisation | CytoplasmPreautophagosomal Structure MembranePeripheral Membrane ProteinEndosome MembraneLysosome MembraneRecruited To Omegasomes Membranes By Wipi2Omegasomes Are Endoplasmic Reticulum Connected Strutures At The Origin Of Preautophagosomal StructuresLocalized To Preautophagosomal Structure (Pas) Where It Is Involved In The Membrane Targeting Of Atg5Localizes Also To Discrete Punctae Along The Ciliary AxonemeUpon Activation Of Non-Canonical AutophagyRecruited To Single-Membrane Endolysosomal Compartments |
| Alternative Protein Names | Autophagy-Related Protein 16-1 proteinApg16-Like 1 proteinATG16L1 proteinAPG16L proteinUNQ9393 proteinPRO34307 protein |
Information sourced from Uniprot.org
