Human ATF6B protein (Recombinant) (N-GST & C-His) (STJP007622)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ATF6B-N-GST & C-His protein was developed from e.coli for the region N-GST & C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ATF6B |
| Gene ID | 1388 |
| Uniprot ID | ATF6B_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ala2-Arg50 |
Additional Info
| Post Translational Modifications | N-glycosylated. During unfolded protein response, a fragment of approximately 60 kDa containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is probably performed sequentially by site-1 (MBTPS1, S1P) and site-2 (MBTPS2, S2P) proteases. |
| Function | Cyclic AMP-dependent transcription factor ATF-6 beta: Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 beta), which is embedded in the endoplasmic reticulum membrane. Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR). Processed cyclic AMP-dependent transcription factor ATF-6 beta: Transcription factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCACGA-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCACGA-3') when NF-Y is bound to ERSE. |
| Protein Name | Cyclic Amp-Dependent Transcription Factor Atf-6 BetaCamp-Dependent Transcription Factor Atf-6 BetaActivating Transcription Factor 6 BetaAtf6-BetaProtein G13Camp Response Element-Binding Protein-Related ProteinCreb-RpCamp-Responsive Element-Binding Protein-Like 1 Cleaved Into - Processed Cyclic Amp-Dependent Transcription Factor Atf-6 Beta |
| Database Links | Reactome: R-HSA-8874177 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane ProteinProcessed Cyclic Amp-Dependent Transcription Factor Atf-6 Beta: NucleusUnder Er Stress The Cleaved N-Terminal Cytoplasmic Domain Translocates Into The Nucleus |
| Alternative Protein Names | Cyclic Amp-Dependent Transcription Factor Atf-6 Beta proteinCamp-Dependent Transcription Factor Atf-6 Beta proteinActivating Transcription Factor 6 Beta proteinAtf6-Beta proteinProtein G13 proteinCamp Response Element-Binding Protein-Related Protein proteinCreb-Rp proteinCamp-Responsive Element-Binding Protein-Like 1 Cleaved Into - Processed Cyclic Amp-Dependent Transcription Factor Atf-6 Beta proteinATF6B proteinCREBL1 proteinG13 protein |
Information sourced from Uniprot.org