Human ATF6B protein (Recombinant) (N-GST & C-His) (STJP007622)

SKU:
STJP007622
£328.50 - £1,437.50
Free Shipping
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ATF6B-N-GST & C-His protein was developed from e. coli and has a target region of N-GST & C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ATF6B
Gene ID: 1388
Uniprot ID: ATF6B_HUMAN
Immunogen Region: Ala2-Arg50
Immunogen: Homo sapiens (Human)
Post Translational Modifications N-glycosylated. During unfolded protein response, a fragment of approximately 60 kDa containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is probably performed sequentially by site-1 (MBTPS1, S1P) and site-2 (MBTPS2, S2P) proteases.
Function Cyclic AMP-dependent transcription factor ATF-6 beta: Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 beta), which is embedded in the endoplasmic reticulum membrane. Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR). Processed cyclic AMP-dependent transcription factor ATF-6 beta: Transcription factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCACGA-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCACGA-3') when NF-Y is bound to ERSE.
Protein Name Cyclic Amp-Dependent Transcription Factor Atf-6 Beta
Camp-Dependent Transcription Factor Atf-6 Beta
Activating Transcription Factor 6 Beta
Atf6-Beta
Protein G13
Camp Response Element-Binding Protein-Related Protein
Creb-Rp
Camp-Responsive Element-Binding Protein-Like 1 Cleaved Into - Processed Cyclic Amp-Dependent Transcription Factor Atf-6 Beta
Database Links Reactome: R-HSA-8874177
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Type Ii Membrane Protein
Processed Cyclic Amp-Dependent Transcription Factor Atf-6 Beta: Nucleus
Under Er Stress The Cleaved N-Terminal Cytoplasmic Domain Translocates Into The Nucleus
Alternative Protein Names Cyclic Amp-Dependent Transcription Factor Atf-6 Beta protein
Camp-Dependent Transcription Factor Atf-6 Beta protein
Activating Transcription Factor 6 Beta protein
Atf6-Beta protein
Protein G13 protein
Camp Response Element-Binding Protein-Related Protein protein
Creb-Rp protein
Camp-Responsive Element-Binding Protein-Like 1 Cleaved Into - Processed Cyclic Amp-Dependent Transcription Factor Atf-6 Beta protein
ATF6B protein
CREBL1 protein
G13 protein

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJP011289 Human SOX9, N-GST & C-His protein (Recombinant) (N-GST & C-His) (STJP011289) E. coli
STJP009619 Human WAS protein (Recombinant) (N-GST & C-His) (STJP009619) E. coli
STJP007410 Human MYL3 protein (Recombinant) (N-GST & C-His) (STJP007410) E. coli
STJP007465 Human FXYD1 protein (Recombinant) (N-GST & C-His) (STJP007465) E. coli
STJP007755 Human RPS26 protein (Recombinant) (N-GST & C-His) (STJP007755) E. coli

Related Products

!